Simulate Bacterial Movement through Chemotaxis
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Typ
Examensarbete på kandidatnivå
Program
Publicerad
2021
Författare
Durgé, Rasmus
Ek, Johan
Fredriksson, Jonny
Logren, Emil
Melhem, Mohamad
Muijs, Rik
Modellbyggare
Tidskriftstitel
ISSN
Volymtitel
Utgivare
Sammanfattning
This thesis describes the development of an agent-based simulation of E. coli chemotaxis in C# and the Unity game engine. The agents use a mathematical model
of the chemical pathway underlying chemotaxis to produce either forward-motion
(running) or rotation (tumbling), in response to the concentration of ligand in their
immediate environment. This model consists of a system of ODEs from Edgington
and Tindall [1] and elements of survival analysis. A tool for analysing data from
these simulations was also developed, and used to make quantitative comparisons
between simulations. This is used to compare our model to a simplified model
of chemotaxis, designed to always display chemotactic behaviour. It is concluded
that both models display chemotactic movement, with the simplified model being
more effective at finding the ligand source, but the ODE-based model being more
adaptive.
Beskrivning
Ämne/nyckelord
chemotaxis , computational biology , agent-based simulation , Unity engine