Multi-sensor System for Non-invasive Online Liquid Analysis and Control in Bioreactors for Tissue and Organ Engineering

Examensarbete för masterexamen

Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12380/192845
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Type: Examensarbete för masterexamen
Master Thesis
Title: Multi-sensor System for Non-invasive Online Liquid Analysis and Control in Bioreactors for Tissue and Organ Engineering
Authors: Fonzo, Vito Di
Ciyako, Shwan
Abstract: Having a controlled environment is a necessity for growing organs and tissues. To with- hold such controlled environment, monitoring devices are used to sense the quality of the perfusion medium. To ensure reproducibility of the experiments, a number of pa- rameters should be monitored and recorded. In this area of medicine, the experimental work requires multiple samples to be grown parallelly, in rather simple bio-reactors and utilization of today's macro scale sensor systems is unfeasible, both economically and practically. Emerging sensors based on micro technology are reducing the size of a multi- sensor systems, and making integration with electronics possible. Optical sensing allows minimally invasive measurements and long life-time. The aim of this thesis is to in- vestigate, design and develop such an integrated multi-sensor system capable of sensing several relevant parameters useful in this field, such as dissolved oxygen, pH, dissolved CO2, temperature, etc. A particular attention is also given to the complete system design in which the sensing devices are placed, in order to provide a comprehensive solution and a collection of best practices. Actuators, useful to maintain the required environmental conditions, will also be investigated and included. The system is meant to be functional in an experimental bioreactor designed and used by a research group in the area of regenerative medicine, sensing the parameters into the perfusion medium. This project was carried on in cooperation with Sahlgrenska University in Gothenburg, professor Suchitra Holgersson, and ACREO AB research institute, associate professor Cristina Rusu, and Chalmers University of Technology, professor Peter Enoksson.
Keywords: Elektroteknik och elektronik;Inbäddad systemteknik;Innovation och entreprenörskap (nyttiggörande);Övrig elektroteknik, elektronik och fotonik;Medicinsk bioteknologi (med inriktning mot cellbiologi);Livsvetenskaper;Medicinsk laboratorievetenskap;Nanovetenskap och nanoteknik;Produktion;Electrical Engineering, Electronic Engineering, Information Engineering;Embedded Systems;Innovation & Entrepreneurship;Other electrical engineering, electronics and photonics;Medical Biotechnology (with a focus on Cell Biology);Life Science;Medical Laboratory Science;Nanoscience & Nanotechnology;Production
Issue Date: 2013
Publisher: Chalmers tekniska högskola / Institutionen för mikroteknologi och nanovetenskap
Chalmers University of Technology / Department of Microtechnology and Nanoscience
Series/Report no.: Technical report MC2 - Department of Microtechnology and Nanoscience, Chalmers University of Technology
URI: https://hdl.handle.net/20.500.12380/192845
Collection:Examensarbeten för masterexamen // Master Theses



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