The effect of PLGA nanoparticles on the adipogenic commitment of human mesenchymal stem cells

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dc.contributor.authorMyrbäck, Simon
dc.contributor.departmentChalmers tekniska högskola / Institutionen för fysik (Chalmers)sv
dc.contributor.departmentChalmers University of Technology / Department of Physics (Chalmers)en
dc.date.accessioned2019-07-03T14:41:28Z
dc.date.available2019-07-03T14:41:28Z
dc.date.issued2017
dc.description.abstractPoly (Lactic-co-Glycolic) Acid (PLGA) is a widely used polymer that is approved to use in biomedical applications. Current studies try to incorporate the versatile nature of the polymer in the biomedical field as drug delivery vectors. This master’s thesis aimed at producing PLGA nanoparticles and determine if they have any effect on the adipogenesis from Human Mesenchymal Stem Cells (hMSCs). Nanoparticles were synthesised by an emulsification-solvent evaporation method which resulted in monodispersed particles with a hydrodynamic radius of 350 nm. The synthesised particles had a potential close to zero indicating of an unstable dispersion. After irradiation, the particles fragmented and aggregated forming both nano and micro sized agglomerates. When exposing the hMSCs to a range of concentrations of the sterilised PLGA nanoparticles, it was shown to have a short term toxicity on hMSCs, but no effect on adipogenesis was detected.
dc.identifier.urihttps://hdl.handle.net/20.500.12380/253691
dc.language.isoeng
dc.setspec.uppsokPhysicsChemistryMaths
dc.subjectBiologiska vetenskaper
dc.subjectGrundläggande vetenskaper
dc.subjectHållbar utveckling
dc.subjectEnergi
dc.subjectInnovation och entreprenörskap (nyttiggörande)
dc.subjectInformations- och kommunikationsteknik
dc.subjectBiological Sciences
dc.subjectBasic Sciences
dc.subjectSustainable Development
dc.subjectEnergy
dc.subjectInnovation & Entrepreneurship
dc.subjectInformation & Communication Technology
dc.titleThe effect of PLGA nanoparticles on the adipogenic commitment of human mesenchymal stem cells
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster Thesisen
dc.type.uppsokH
local.programmeBiotechnology (MPBIO), MSc
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