Human peripheral B cell development

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dc.contributor.authorHolmqvist, Joel
dc.contributor.departmentChalmers tekniska högskola / Institutionen för kemi- och biotekniksv
dc.contributor.departmentChalmers University of Technology / Department of Chemical and Biological Engineeringen
dc.date.accessioned2019-07-03T12:32:36Z
dc.date.available2019-07-03T12:32:36Z
dc.date.issued2011
dc.description.abstractSince the middle of the nineties, our understanding of human peripheral B cell development has gradually increased. Today, the B cell compartment has been divided into three main populations; transitional, naive and memory B cells. In Mats Bermark's laboratorium, a cell surface marker identifying a novel peripheral B cell population has been found. The work performed during this thesis aimed to characterize the novel B cell population by comparing it with the major already described peripheral B cell populations. Novel B cells were found to be smaller than memory B cells. The antibody genes were found to contain less mutations than those of memory B cells. Furthermore, novel B cells were found to be less prone to enter apoptosis than transitional B cells. A screening experiment using flow cytometry added support to the hypothesis that the novel B cells are different from the already described populations. The results suggests that the novel B cell population is a distinct subpopulation post- or parallel to the naive population. Novel B cells might be able to differentiate into IgM+ memory B cells. In order to verify this, new experiments are needed
dc.identifier.urihttps://hdl.handle.net/20.500.12380/138137
dc.language.isoeng
dc.setspec.uppsokPhysicsChemistryMaths
dc.subjectEnergi
dc.subjectLivsvetenskaper
dc.subjectIndustriell bioteknik
dc.subjectEnergy
dc.subjectLife Science
dc.subjectIndustrial Biotechnology
dc.titleHuman peripheral B cell development
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster Thesisen
dc.type.uppsokH
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