Development of a semi-automated covalent binding methodology

Abstract

A semi-automated in vitro covalent binding assay with the marketed compounds acetaminophen, amodiaquine, carbamazepine, clozapine, diclofenac, troglitazone, and zomepirac has been used to evaluate the applicability of a zone classification system proposed by Nakayama, et al., 2009*. The zone classification system takes into consideration daily dose of each drug together with the generated amount of covalent binding from the assay. *Reference in thesis