THz Imaging of Roll Compaction for Pharmaceutical Applications

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dc.contributor.authorGarcia Wernersson, Joakim
dc.contributor.departmentChalmers tekniska högskola / Institutionen för mikroteknologi och nanovetenskapsv
dc.contributor.departmentChalmers University of Technology / Department of Microtechnology and Nanoscienceen
dc.date.accessioned2019-07-03T14:17:49Z
dc.date.available2019-07-03T14:17:49Z
dc.date.issued2016
dc.description.abstractIn the pharmaceutical industry, dry granulation is an intermediate state in the tablet manufacturing process for orally administered products. Powder blends with poor flowing properties are compressed and milled producing a granular material with increased flow properties. A key element in the process is the density of the compressed powder since it will affect the final quality of the manufactured tablet.The existing density measurement system employed by AstraZeneca is a destructive measurement. This thesis shows a method for non-destructive density measurements using a terahertz imaging system. A model of the relation between the phase of the THz transmitted signal versus the permittivity of the sample was obtained through fullwave simulations using CST Microwave Studio. By determining the permittivity of samples with known density, a material specific model of how the permittivity varies with density was obtained. The presented density control method has significantly decreased the measurement time by a factor of 2 and it is also capable of measuring the density over a 20 times smaller area of the sample compared with the method currently used at AstraZeneca.
dc.identifier.urihttps://hdl.handle.net/20.500.12380/240675
dc.language.isoeng
dc.setspec.uppsokPhysicsChemistryMaths
dc.subjectInformations- och kommunikationsteknik
dc.subjectLivsvetenskaper
dc.subjectHållbar utveckling
dc.subjectÖvrig elektroteknik, elektronik och fotonik
dc.subjectBioteknisk apparatteknik
dc.subjectInformation & Communication Technology
dc.subjectLife Science
dc.subjectSustainable Development
dc.subjectOther electrical engineering, electronics and photonics
dc.subjectBioengineering Equipment
dc.titleTHz Imaging of Roll Compaction for Pharmaceutical Applications
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster Thesisen
dc.type.uppsokH
local.programmeWireless, photonics and space engineering (MPWPS), MSc
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