HSC development and location of Hoxb5 positive cells during gastrulation and early organogenesis in the fetal liver

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dc.contributor.advisorProfessor Irving Weissman, Stanford University
dc.contributor.authorWegnelius, Tuva
dc.contributor.departmentChalmers tekniska högskola / Institutionen för biologi och biotekniksv
dc.contributor.examinerJoakim Norbeck
dc.date.accessioned2020-02-11T08:16:38Z
dc.date.available2020-02-11T08:16:38Z
dc.date.issued2019sv
dc.date.submitted2019
dc.description.abstractHematopoietic stem cells (HSC) have the ability to self-renew and are responsible for the production of all blood and immune cells. These properties of the cells are used in clinical applications for treating malignant and non-malignant diseases with well-established HSC transplants. HSCs are today in short supply. To produce HSCs in vitro, a deeper knowledge of the development of HSCs is needed. The aim of this study was to interrogate HSC development during embryogenesis. Hoxb5, the long term adult HSC marker was studied in the context of HSC development. Cells expressing Hoxb5 were isolated by multiparameter fluorescent antibody cell sorting. Hoxb5 was also localized in resident tissues by innovative staining and microscopy techniques. The understanding of the developmental niche of phenotypic HSCs expressing Hoxb5 will provide important functional information, which will facilitate in vitro generation of HSCs.sv
dc.identifier.coursecodeBBTX60sv
dc.identifier.urihttps://hdl.handle.net/20.500.12380/300676
dc.language.isoengsv
dc.setspec.uppsokLifeEarthScience
dc.subjectHSCsv
dc.subjectembryogenesissv
dc.subjectCRISPRsv
dc.titleHSC development and location of Hoxb5 positive cells during gastrulation and early organogenesis in the fetal liversv
dc.type.degreeExamensarbete för masterexamensv
dc.type.uppsokH
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