Dynamics and stabilization mechanisms of amorphous solid dispersions

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dc.contributor.authorWanemark, Joel
dc.contributor.departmentChalmers tekniska högskola / Institutionen för fysik (Chalmers)sv
dc.contributor.departmentChalmers University of Technology / Department of Physics (Chalmers)en
dc.date.accessioned2019-07-03T14:24:50Z
dc.date.available2019-07-03T14:24:50Z
dc.date.issued2016
dc.description.abstractA growing problem in the pharmaceutical industry is the poor water-solubility of new candidate drugs22, 41. It is estimated that 75% of drugs under development are considered to have poor water-solubility19, and a low solubility heavily diminishes the chance of drug uptake and therapeutic effect. A method that has recieved attention lately to achieve increased solubility is to make use of a formulation strategy known as an amorphous solid dispersion (ASD)13, 31. The amorphous state of the pharmaceutical eliminates the impact of lattice energy resulting in increased solubility. However, since the pharmaceutical is in its thermodynamically metastable amorphous state, the dispersion may crystallize over relevant pharmaceutical timescales thus cancelling the solubility advantage. Stabilizing amorphous pharmaceuticals with polymers in ASDs have proven possible in previous studies5, 42, 63, 59, although the stabilization has been attributed to different mechanisms. In this work, the relationship between anti-plasticization effects and hydrogen bonding was investigated in ASDs with ibuprofen and felodipine using dielectric spectroscopy, differential scanning calorimetry and FTIR spectroscopy. The physical stability of ibuprofen was drastically improved, stabilizing the drug in its amorphous state over a timescale of months. It was found that the polymeric glass transition temperature of the polymer did not correlate with the stabilization effect of ibuprofen. The effect was instead attributed to hydrogen bonding between polymer and ibuprofen. Dispersions using felodipine were however not succesfully prepared.
dc.identifier.urihttps://hdl.handle.net/20.500.12380/247186
dc.language.isoeng
dc.setspec.uppsokPhysicsChemistryMaths
dc.subjectMaterialvetenskap
dc.subjectGrundläggande vetenskaper
dc.subjectHållbar utveckling
dc.subjectAnnan teknik
dc.subjectMaterials Science
dc.subjectBasic Sciences
dc.subjectSustainable Development
dc.subjectOther Engineering and Technologies
dc.titleDynamics and stabilization mechanisms of amorphous solid dispersions
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster Thesisen
dc.type.uppsokH
local.programmeApplied physics (MPAPP), MSc
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