Human peripheral B cell development

Examensarbete för masterexamen

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Type: Examensarbete för masterexamen
Master Thesis
Title: Human peripheral B cell development
Authors: Holmqvist, Joel
Abstract: Since the middle of the nineties, our understanding of human peripheral B cell development has gradually increased. Today, the B cell compartment has been divided into three main populations; transitional, naive and memory B cells. In Mats Bermark's laboratorium, a cell surface marker identifying a novel peripheral B cell population has been found. The work performed during this thesis aimed to characterize the novel B cell population by comparing it with the major already described peripheral B cell populations. Novel B cells were found to be smaller than memory B cells. The antibody genes were found to contain less mutations than those of memory B cells. Furthermore, novel B cells were found to be less prone to enter apoptosis than transitional B cells. A screening experiment using flow cytometry added support to the hypothesis that the novel B cells are different from the already described populations. The results suggests that the novel B cell population is a distinct subpopulation post- or parallel to the naive population. Novel B cells might be able to differentiate into IgM+ memory B cells. In order to verify this, new experiments are needed
Keywords: Energi;Livsvetenskaper;Industriell bioteknik;Energy;Life Science;Industrial Biotechnology
Issue Date: 2011
Publisher: Chalmers tekniska högskola / Institutionen för kemi- och bioteknik
Chalmers University of Technology / Department of Chemical and Biological Engineering
Collection:Examensarbeten för masterexamen // Master Theses

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