X-ray fragment screening of MEK1 to identify allosteric fragment binders

Examensarbete för masterexamen

Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12380/255985
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Type: Examensarbete för masterexamen
Master Thesis
Title: X-ray fragment screening of MEK1 to identify allosteric fragment binders
Authors: Möller, Carl
Abstract: The drug development process includes several phases and often span over many years. The initial phases are directed towards identifying and validating a potential target. Once a target has been validated, the hit identification and lead discovery process is initiated. This project have been performed on behalf of AstraZeneca and aimed to use x-ray crystallography to screen a compound library to identify fragments that binds to the allosteric pocket of MEK1. The results from this screen have mapped how a library of selected small molecules bound to the allosteric site. In total the campaign yielded 24 bound fragments with a good diversity that probes the entire pocket in a eÿcient way.
Keywords: Annan medicinsk grundvetenskap;Livsvetenskaper;Strukturbiologi;Medicinsk bioteknologi (med inriktning mot cellbiologi);Other Basic Medicine;Life Science;Structural Biology;Medical Biotechnology (with a focus on Cell Biology)
Issue Date: 2018
Publisher: Chalmers tekniska högskola / Institutionen för biologi och bioteknik
Chalmers University of Technology / Department of Biology and Biological Engineering
URI: https://hdl.handle.net/20.500.12380/255985
Collection:Examensarbeten för masterexamen // Master Theses



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