X-ray fragment screening of MEK1 to identify allosteric fragment binders

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dc.contributor.authorMöller, Carl
dc.contributor.departmentChalmers tekniska högskola / Institutionen för biologi och biotekniksv
dc.contributor.departmentChalmers University of Technology / Department of Biology and Biological Engineeringen
dc.date.accessioned2019-07-03T14:53:03Z
dc.date.available2019-07-03T14:53:03Z
dc.date.issued2018
dc.description.abstractThe drug development process includes several phases and often span over many years. The initial phases are directed towards identifying and validating a potential target. Once a target has been validated, the hit identification and lead discovery process is initiated. This project have been performed on behalf of AstraZeneca and aimed to use x-ray crystallography to screen a compound library to identify fragments that binds to the allosteric pocket of MEK1. The results from this screen have mapped how a library of selected small molecules bound to the allosteric site. In total the campaign yielded 24 bound fragments with a good diversity that probes the entire pocket in a eÿcient way.
dc.identifier.urihttps://hdl.handle.net/20.500.12380/255985
dc.language.isoeng
dc.setspec.uppsokLifeEarthScience
dc.subjectAnnan medicinsk grundvetenskap
dc.subjectLivsvetenskaper
dc.subjectStrukturbiologi
dc.subjectMedicinsk bioteknologi (med inriktning mot cellbiologi)
dc.subjectOther Basic Medicine
dc.subjectLife Science
dc.subjectStructural Biology
dc.subjectMedical Biotechnology (with a focus on Cell Biology)
dc.titleX-ray fragment screening of MEK1 to identify allosteric fragment binders
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster Thesisen
dc.type.uppsokH
local.programmeBiotechnology (MPBIO), MSc
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