X-ray fragment screening of MEK1 to identify allosteric fragment binders

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Examensarbete för masterexamen
Master Thesis
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2018
Författare
Möller, Carl
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The drug development process includes several phases and often span over many years. The initial phases are directed towards identifying and validating a potential target. Once a target has been validated, the hit identification and lead discovery process is initiated. This project have been performed on behalf of AstraZeneca and aimed to use x-ray crystallography to screen a compound library to identify fragments that binds to the allosteric pocket of MEK1. The results from this screen have mapped how a library of selected small molecules bound to the allosteric site. In total the campaign yielded 24 bound fragments with a good diversity that probes the entire pocket in a eÿcient way.
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Ämne/nyckelord
Annan medicinsk grundvetenskap, Livsvetenskaper, Strukturbiologi, Medicinsk bioteknologi (med inriktning mot cellbiologi), Other Basic Medicine, Life Science, Structural Biology, Medical Biotechnology (with a focus on Cell Biology)
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