X-ray fragment screening of MEK1 to identify allosteric fragment binders

Typ
Examensarbete för masterexamen
Master Thesis
Program
Biotechnology (MPBIO), MSc
Publicerad
2018
Författare
Möller, Carl
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Sammanfattning
The drug development process includes several phases and often span over many years. The initial phases are directed towards identifying and validating a potential target. Once a target has been validated, the hit identification and lead discovery process is initiated. This project have been performed on behalf of AstraZeneca and aimed to use x-ray crystallography to screen a compound library to identify fragments that binds to the allosteric pocket of MEK1. The results from this screen have mapped how a library of selected small molecules bound to the allosteric site. In total the campaign yielded 24 bound fragments with a good diversity that probes the entire pocket in a eÿcient way.
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Ämne/nyckelord
Annan medicinsk grundvetenskap , Livsvetenskaper , Strukturbiologi , Medicinsk bioteknologi (med inriktning mot cellbiologi) , Other Basic Medicine , Life Science , Structural Biology , Medical Biotechnology (with a focus on Cell Biology)
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