Fokuserad uppvärmning av hjärnan med hypertermi

Abstract

Combining radiation or chemotherapy with hyperthermia has been shown to be an effective way to improve cancer treatments. This project has investigated which temparature is obtainable when using focused heating on cancer tumors. The tumor used in the project is a deep-seated medulloblastoma in a child model. Tumor coverage and hot spots have been considered. Electromagnetic fields were simulated on the model and the results were optimized using a goal function. The results show a certain heating of the deep-seated tumor, but with hot spots and very low coverage of the tumor. Different goal functions used for optimization were also examined, along with methods of optimization. These results indicated that Nelder-Mead is a better method of optimization than particle swarm for this case and that the new goal function HTC25 gave equivalent results as the commonly used HTQ.