Systematic evaluation of different approaches for modelling inhaled particle deposition in the lung airways
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Typ
Examensarbete för masterexamen
Program
Applied mechanics (MPAME), MSc
Publicerad
2022
Författare
Abram, Hari
Modellbyggare
Tidskriftstitel
ISSN
Volymtitel
Utgivare
Sammanfattning
A typical path model is an algebraic model utilized to predict the particle deposition
in the lung airway geometry. Prediction of particle deposition is an essential part
of the drug discovery and manufacturing process. The accuracy of the typical path
algebraic model is to be verified and quantified to establish the model’s use in future
applications.
There exists a variety of typical path models from various authors for particle deposition,
this project starts with the comparison of deposition of particles between
individual authors and justifies the differences observed between different authors
based on the assumptions from which these models are derived. Subsequently, lung
CAD geometry is created based on the Yeh and Schum lung dimensions, to properly
capture the topology of the lung bifurcations an engineering decision is made to
adjust the branching of parent branch into daughter branches.
CFD simulations are performed on the CAD model with the open-source software
OpenFOAM. With an inlet flow rate of 60 l/min, the particles are injected into the
air, to observe their position of deposition and compare the results of CFD with the
typical path model. Deposition efficiency observed for these methods is analyzed and
similar and dissimilar general trends are justified. To properly capture the regional
deposition the first generation of the lung morphology is divided into different parts,
and deposition efficiency in each branch is presented, furthermore observed trends
are introduced contrasting the typical path model’s broad assumptions.
Beskrivning
Ämne/nyckelord
Typical path model , CFD , lung geometry , deposition efficiency , bifurcations , OpenFOAM