Bulk Properties of Highly Polydisperse Particle Assemblies
Typ
Examensarbete för masterexamen
Master's Thesis
Master's Thesis
Program
Engineering mathematics and computational science (MPENM), MSc
Publicerad
2023
Författare
Flensburg , Ivan
Westberg, Filip
Modellbyggare
Tidskriftstitel
ISSN
Volymtitel
Utgivare
Sammanfattning
Pharmaceutical oral drug products often come in the form of highly polydisperse
multi-component granular powders. Drug development is limited by experimental
testing, making in silico methods a valuable alternative approach. To this end, a
framework was developed using Discrete Element Method which simulates arbitrary
assemblies at or below jamming density, of spherical frictionless particles.
Analytic formulations for the component concentration homogeneity are compared
against simulation results, where that of Stange proved to be more appropriate
than Hilden. The packing fraction variability influences the content homogeneity.
This variability was then compared to that of a packing model, and show some
proportionality, though requiring further work to model one through the other. A
simulation scale should have been formulated through a maximum packing fraction
variability and content inhomogeneity, as its lack was visible due to its effect on the
content homogeneity.
Beskrivning
Ämne/nyckelord
Discrete Element Method, Content Uniformity, highly polydisperse