Bulk Properties of Highly Polydisperse Particle Assemblies

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dc.contributor.authorFlensburg , Ivan
dc.contributor.authorWestberg, Filip
dc.contributor.departmentChalmers tekniska högskola / Institutionen för matematiska vetenskapersv
dc.contributor.examinerGeynts, Alexey
dc.contributor.supervisorde Juan, Luis Martin
dc.contributor.supervisorBoje, Astrid
dc.date.accessioned2023-10-16T12:40:26Z
dc.date.available2023-10-16T12:40:26Z
dc.date.issued2023
dc.date.submitted2023
dc.description.abstractPharmaceutical oral drug products often come in the form of highly polydisperse multi-component granular powders. Drug development is limited by experimental testing, making in silico methods a valuable alternative approach. To this end, a framework was developed using Discrete Element Method which simulates arbitrary assemblies at or below jamming density, of spherical frictionless particles. Analytic formulations for the component concentration homogeneity are compared against simulation results, where that of Stange proved to be more appropriate than Hilden. The packing fraction variability influences the content homogeneity. This variability was then compared to that of a packing model, and show some proportionality, though requiring further work to model one through the other. A simulation scale should have been formulated through a maximum packing fraction variability and content inhomogeneity, as its lack was visible due to its effect on the content homogeneity.
dc.identifier.coursecodeMVEX03
dc.identifier.urihttp://hdl.handle.net/20.500.12380/307229
dc.language.isoeng
dc.setspec.uppsokPhysicsChemistryMaths
dc.subjectDiscrete Element Method, Content Uniformity, highly polydisperse
dc.titleBulk Properties of Highly Polydisperse Particle Assemblies
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster's Thesisen
dc.type.uppsokH
local.programmeEngineering mathematics and computational science (MPENM), MSc
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