Development of HighWater Content Tissue Phantoms for Quality Assurance in Hyperthermia
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Typ
Examensarbete för masterexamen
Master's Thesis
Master's Thesis
Program
Biotechnology (MPBIO), MSc
Publicerad
2024
Författare
Huseyin, Cengizhan
Modellbyggare
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Volymtitel
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Sammanfattning
Abstract
As cancer persists as a notable health challenge worldwide, novel therapeutic approaches are required to complement current treatment modalities. Hyperthermia therapy is recognized to be an effective approach, which can be combined with either chemotherapy or radiation therapy in order to effectively treat tumors using electromagnetic radiation to generate heat. Depending on the size, depth and location of the tumor, various heating devices are used for treatment. Radiative microwave and radio-wave systems are commonly used for the treatment of deep-seated tumors in larger anatomical regions, operating within the lower frequency range of 70-120 MHz. To ensure that these devices can deliver adequate heat within the targeted area, adherence to quality assurance guidelines protocols are important. These guidelines are pivotal for maintaining the quality of heating devices as well as protecting the health of individuals receiving treatment. The evaluation of device performance is conducted through the utilization of physical materials known as phantoms. The purpose of using phantoms is to replicate the biological and dielectric properties of tissues in the human body. Depending on the specific tumor being treated, various phantom materials can be used and combined with each other in order to simulate the properties of the tissues where the tumor is located. It is essential for these phantoms to possess sufficient mechanical strength to be able to endure the experimental conditions, as they will be subjected to heat in clinical trials. In this thesis, hydroxyethylcellulose was used as a ground component in conjunction with agar, glycerol and salt to fabricate a mechanically stable phantom that mimics the dielectric properties of muscle tissue, with the aim of treating deep-seated tumors. To achieve a functioning phantom possessing the desired properties, an optimization of the process was performed by analyzing various parameters in regards to concentration, molecular weight and air bubble formation.
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Keywords: Hyperthermia Therapy, Chemotherapy, Radiation Therapy, Radiative Systems, Phantoms, Hydroxyethylcellulose, Agar, Glycerol, Salt.