Fluid-Structure Interaction Analysis of Carotid Artery Blood Flow. A Patient-Specific Investigation of the Impact of Arterial Wall Deformation on Hemodynamics.
Typ
Examensarbete för masterexamen
Program
Biomedical engineering (MPBME), MSc
Publicerad
2022
Författare
Nordenström, Simon
Modellbyggare
Tidskriftstitel
ISSN
Volymtitel
Utgivare
Sammanfattning
Cardiovascular disease, predominantly caused by atherosclerosis, is the leading cause
of death worldwide. Therefore, scientific methods capable of accurately evaluating
risk factors of cardiovascular disease on a patient-specific basis are highly soughtafter.
Typically, numerical approaches for simulating blood flow assume arterial
walls to be rigid structures. However, to obtain more physiologically realistic simulations,
the interplay between wall deformation and blood flow, the so-called fluidstructure
interaction (FSI), must be taken into consideration. In this project, a
workflow is established for performing patient-specific FSI simulations of blood flow
and arterial wall deformation in the carotid artery – the main source of blood supply
to the brain. The workflow is primarily intended to aid in the execution of FSI
analyses in the STAR-CCM+ simulation software. Furthermore, the impact of FSI
on hemodynamic parameters such as flow velocity, wall shear stress, and oscillatory
shear index, is quantified and analyzed for a patient-specific geometry. It is shown
that a rigid wall assumption results in underestimations of the areas associated with
an increased risk of atherosclerosis, namely regions of low time-averaged wall shear
stress and high oscillatory shear index. Moreover, the rigid wall assumption leads
to overestimations of the flow velocities during the systolic phase of the cardiac cycle.
FSI analyses are performed using three different material models: an isotropic
linear elastic model, a Neo-Hookean model, and a Mooney-Rivlin model. For the
specific boundary conditions and parameter values employed, marginal differences
are observed in the hemodynamics between the three material models.
Beskrivning
Ämne/nyckelord
FSI, Carotid artery, Simulation, Hemodynamics,Workflow, STAR-CCM+.