Structure of amyloid fibrils. A computational analysis

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dc.contributor.authorErngren, Josefin
dc.contributor.authorKarlsson, Kerstin
dc.contributor.authorQvick, Jan
dc.contributor.authorStigsson, Anders
dc.contributor.authorTobin, Johan
dc.contributor.departmentChalmers tekniska högskola / Institutionen för data- och informationsteknik (Chalmers)sv
dc.contributor.departmentChalmers University of Technology / Department of Computer Science and Engineering (Chalmers)en
dc.date.accessioned2019-07-03T14:23:31Z
dc.date.available2019-07-03T14:23:31Z
dc.date.issued2016
dc.description.abstractAmyloid fibrils are misfolded proteins related to several different diseases, such as Alzheimer’s and Parkinson’s disease. The aims of the report are to computationally analyze significant patterns and distributions of certain amino acids in the structure of amyloid fibrils. The direction relative to the fibril core is investigated for the charged amino acids and those present in bends. Amino acids in the amyloid fibrils tend to stack upon each other, these stacks are identified for the amino acids containing aromatic rings and the tilt of the aromatic rings are calculated relative to the axis of the fibril. The result from the analysis of the bends does not show significant patterns exclusive to amyloid fibrils, while the analysis of the charged amino acids indicates that they tend to face outwards relative to the fibril core. The tilt of the aromatic rings tends to be distributed around 55°. The results are consistent with previous findings and provide some information which could be of use when predicting the structure of amyloid fibrils.
dc.identifier.urihttps://hdl.handle.net/20.500.12380/245108
dc.language.isoeng
dc.setspec.uppsokTechnology
dc.subjectInformations- och kommunikationsteknik
dc.subjectData- och informationsvetenskap
dc.subjectInformation & Communication Technology
dc.subjectComputer and Information Science
dc.titleStructure of amyloid fibrils. A computational analysis
dc.type.degreeExamensarbete för kandidatexamensv
dc.type.degreeBachelor Thesisen
dc.type.uppsokM2
local.programmeBioteknik 300 hp (civilingenjör)
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